The ability of the natural chemoprophylactic agent curcumin to function as an effective UV photosensitiser

It is known that some plant polyphenols and alkaloids can act as effective photosensitisers of UV radiation. This phenomenon enhance both therapeutic side effects. Since there no information regarding curcuminoids on their ability to function photosensitisers, this work investigated the effect radiation cytotoxic curcumin, well its nanostructured forms, against keratinocytes HaCaT line cancer cells MDA-MB-231. The results obtained indicate curcumin an photosensitiser capable initiating photochemical reactions under influence A B range, which lead formation chemically active intermediates, disruption membrane integrity cell death. When incorporated into nanostructures based polyallylamine hydrochloride /polystyrene sulfate chitosan /dextran sulfate, a retained.